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Cancer Res. 2017 Nov 1;77(21):e58-e61. doi: 10.1158/0008-5472.CAN-17-0606.

NDEx 2.0: A Clearinghouse for Research on Cancer Pathways.

Author information

1
Department of Medicine, University of California San Diego, La Jolla, California. depratt@ucsd.edu.
2
Department of Medicine, University of California San Diego, La Jolla, California.
3
Department of Computer Science and Engineering, University of California San Diego, La Jolla, California.

Abstract

We present NDEx 2.0, the latest release of the Network Data Exchange (NDEx) online data commons (www.ndexbio.org) and the ways in which it can be used to (i) improve the quality and abundance of biological networks relevant to the cancer research community; (ii) provide a medium for collaboration involving networks; and (iii) facilitate the review and dissemination of networks. We describe innovations addressing the challenges of an online data commons: scalability, data integration, data standardization, control of content and format by authors, and decentralized mechanisms for review. The practical use of NDEx is presented in the context of a novel strategy to foster network-oriented communities of interest in cancer research by adapting methods from academic publishing and social media. Cancer Res; 77(21); e58-61. ©2017 AACR.

PMID:
29092941
PMCID:
PMC5679399
DOI:
10.1158/0008-5472.CAN-17-0606
[Indexed for MEDLINE]
Free PMC Article

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