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J Am Heart Assoc. 2017 Nov 1;6(11). pii: e006241. doi: 10.1161/JAHA.117.006241.

Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study.

Author information

1
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
2
Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA.
3
Division of Cardiology, Kyung Hee University Hospital, Seoul, Republic of Korea.
4
Cardiovascular Medicine, Kawasaki Medical School, Kurashiki, Japan.
5
Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
6
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA ijang@mgh.harvard.edu.

Abstract

BACKGROUND:

Previous studies have demonstrated that statin therapy improves cardiac outcomes, probably by stabilizing thin-cap fibroatheroma in patients with coronary artery disease. However, major adverse cardiac events still occur in some patients, despite statin therapy. The aim of this study is to identify clinical predictors for the lack of a favorable vascular response to statin therapy in patients with coronary artery disease.

METHODS AND RESULTS:

A total of 140 nonculprit plaques from 84 patients with coronary artery disease who were treated with a statin and had serial optical coherence tomography imaging (median interval, 6.3 months) were included. Thin-cap area (fibrous cap thickness, <200 μm) was measured using a novel 3-dimensional computer-aided algorithm. Overall, the thin-cap area significantly decreased from baseline (median, 2.852 mm2; 25th-75th percentile, 1.023-6.157 mm2) to follow-up (median, 1.210 mm2; 25th-75th percentile, 0.250-3.192 mm2; P<0.001), and low-density lipoprotein cholesterol significantly decreased from baseline (mean±SD, 92.9±30.1 mg/dL) to follow-up (mean±SD, 76.3±23.3 mg/dL; P<0.001). The general linear model with multiple predictor variables revealed that the thin-cap area was significantly higher in patients with chronic kidney disease than in those without it (regression coefficient b, 1.691 mm2; 95% confidence interval, 0.350-3.033 mm2; P=0.013) and lower in patients with acute coronary syndrome (regression coefficient b, -1.535 mm2; 95% confidence interval, -2.561 to -0.509 mm2; P=0.003).

CONCLUSIONS:

Chronic kidney disease is an independent predictor for the lack of a favorable vascular response to statin therapy, whereas acute coronary syndrome is an independent predictor for favorable vascular response to statin therapy. These findings should be further warranted in future prospective studies.

CLINICAL TRIAL REGISTRATION:

URL: http://www.clinicaltrials.gov. Unique identifier: NCT01110538.

KEYWORDS:

atherosclerosis; coronary artery disease; fibrous cap; optical coherence tomography; statin therapy

PMID:
29092845
PMCID:
PMC5721742
DOI:
10.1161/JAHA.117.006241
[Indexed for MEDLINE]
Free PMC Article

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