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Clin Infect Dis. 2017 Oct 30;65(10):1601-1606. doi: 10.1093/cid/cix848.

2017 HIV Medicine Association of Infectious Diseases Society of America Clinical Practice Guideline for the Management of Chronic Pain in Patients Living With Human Immunodeficiency Virus.

Author information

Department of Medicine, Cornell Scott-Hill Health Center and Yale University, New Haven, Connecticut.
Divisions of Infectious Diseases and Gerontology, Geriatrics and Palliative Care, University of Alabama at Birmingham.
Division of HIV, Infectious Disease, and Global Medicine, University of California San Francisco.
St. Johns University College of Pharmacy and Health Sciences, Metropolitan Jewish Health System Institute for Innovation in Palliative Care, New York, New York.
University of Maryland School of Medicine, Institute of Human Virology, Baltimore.
Eshelman School of Pharmacy, University of North Carolina, Chapel Hill.
Memorial Sloan Kettering Cancer Center, New York, New York.
Division of Neuroscience and Clinical Pharmacology, Cornell University, New York, New York.
Division of HIV Medicine, Johns Hopkins Medical Center, Baltimore, Maryland.
Department of Family and Social Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.


Pain has always been an important part of human immunodeficiency virus (HIV) disease and its experience for patients. In this guideline, we review the types of chronic pain commonly seen among persons living with HIV (PLWH) and review the limited evidence base for treatment of chronic noncancer pain in this population. We also review the management of chronic pain in special populations of PLWH, including persons with substance use and mental health disorders. Finally, a general review of possible pharmacokinetic interactions is included to assist the HIV clinician in the treatment of chronic pain in this population.It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. The Infectious Diseases Society of American considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.

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