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J Neurovirol. 2018 Feb;24(1):113-118. doi: 10.1007/s13365-017-0588-y. Epub 2017 Oct 31.

Aging alters voltage-gated calcium channels in prefrontal cortex pyramidal neurons in the HIV brain.

Author information

1
Department of Immunology and Microbiology, Rush University Medical Center, Cohn Research Building, Rm.414, 1735 W. Harrison Street, Chicago, IL, 60612, USA.
2
Department of Immunology and Microbiology, Rush University Medical Center, Cohn Research Building, Rm.414, 1735 W. Harrison Street, Chicago, IL, 60612, USA. xiu-ti_hu@rush.edu.

Abstract

We assessed firing and voltage-gated Ca2+ influx in medial prefrontal cortex (mPFC) pyramidal neurons from older (12 months old) HIV-1 transgenic (Tg) rats. We found that neurons from older Tg rats showed increased firing compared to non-Tg rats, but Ca2+ spikes were unchanged. However, stronger excitatory stimulation was needed to evoke Ca2+ spikes, which was associated with reduced mPFC Cav1.2 L-type Ca2+ channel (L-channel) protein. In contrast, L-channel protein was unaltered in younger (6-7 weeks old) Tg rats, which we previously found had enhanced neuronal Ca2+ influx. These studies demonstrate that aging alters HIV-induced Ca2+ channel dysfunction that affects mPFC activity.

KEYWORDS:

Calcium; HAND; HIV; HIV-1 Tg rat; L-channel; Medial prefrontal cortex

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