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Nat Commun. 2017 Nov 1;8(1):1242. doi: 10.1038/s41467-017-01356-z.

History-based action selection bias in posterior parietal cortex.

Author information

1
Neurobiology Section, Center for Neural Circuits and Behavior, Department of Neurosciences, University of California, San Diego, La Jolla, CA, 92093, USA. eunjunghwang.phd@gmail.com.
2
Neurobiology Section, Center for Neural Circuits and Behavior, Department of Neurosciences, University of California, San Diego, La Jolla, CA, 92093, USA.
3
Neurobiology Section, Center for Neural Circuits and Behavior, Department of Neurosciences, University of California, San Diego, La Jolla, CA, 92093, USA. tkomiyama@ucsd.edu.
4
JST, PRESTO, University of California, San Diego, La Jolla, CA, 92093, USA. tkomiyama@ucsd.edu.

Abstract

Making decisions based on choice-outcome history is a crucial, adaptive ability in life. However, the neural circuit mechanisms underlying history-dependent decision-making are poorly understood. In particular, history-related signals have been found in many brain areas during various decision-making tasks, but the causal involvement of these signals in guiding behavior is unclear. Here we addressed this issue utilizing behavioral modeling, two-photon calcium imaging, and optogenetic inactivation in mice. We report that a subset of neurons in the posterior parietal cortex (PPC) closely reflect the choice-outcome history and history-dependent decision biases, and PPC inactivation diminishes the history dependency of choice. Specifically, many PPC neurons show history- and bias-tuning during the inter-trial intervals (ITI), and history dependency of choice is affected by PPC inactivation during ITI and not during trial. These results indicate that PPC is a critical region mediating the subjective use of history in biasing action selection.

PMID:
29089500
PMCID:
PMC5663966
DOI:
10.1038/s41467-017-01356-z
[Indexed for MEDLINE]
Free PMC Article

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