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Development. 2017 Nov 1;144(21):3867-3878. doi: 10.1242/dev.132852.

Cortical interneuron development: a tale of time and space.

Author information

1
Department of Psychiatry, University of California, San Francisco, CA 94158, USA.
2
Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, CA 94158, USA.
3
Department of Psychiatry, University of California, San Francisco, CA 94158, USA john.rubenstein@ucsf.edu.

Abstract

Cortical interneurons are a diverse group of neurons that project locally and are crucial for regulating information processing and flow throughout the cortex. Recent studies in mice have advanced our understanding of how these neurons are specified, migrate and mature. Here, we evaluate new findings that provide insights into the development of cortical interneurons and that shed light on when their fate is determined, on the influence that regional domains have on their development, and on the role that key transcription factors and other crucial regulatory genes play in these events. We focus on cortical interneurons that are derived from the medial ganglionic eminence, as most studies have examined this interneuron population. We also assess how these data inform our understanding of neuropsychiatric disease and discuss the potential role of cortical interneurons in cell-based therapies.

KEYWORDS:

Cell fate; Cortical interneurons; MGE; Parvalbumin; Somatostatin; Transcription factors

PMID:
29089360
PMCID:
PMC5702067
[Available on 2018-11-01]
DOI:
10.1242/dev.132852
[Indexed for MEDLINE]
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