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Trends Endocrinol Metab. 2017 Dec;28(12):831-842. doi: 10.1016/j.tem.2017.10.003. Epub 2017 Oct 28.

Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism.

Author information

1
School of Medicine and Public Health, Endocrinology and Reproductive Physiology Graduate Training Program, University of Wisconsin-Madison, Madison, WI 53706, USA; King Saud bin Abdulaziz University for Health Sciences, National Guard Health Affairs, Riyadh, 11426, Saudi Arabia.
2
School of Medicine and Public Health, Department of Dermatology, University of Wisconsin-Madison, Madison, WI 53706, USA.
3
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: james.ntambi@wisc.edu.

Abstract

Stearoyl-coenzyme A desaturase 1 (SCD1) is a central regulator of fuel metabolism and may represent a therapeutic target to control obesity and the progression of related metabolic diseases including type 2 diabetes and hepatic steatosis. SCD1 catalyzes the synthesis of monounsaturated fatty acids (MUFAs), mainly oleate and palmitoleate, which are important in controlling weight gain in response to feeding high carbohydrate diets. In this review, we evaluate the role of SCD1 isoform in the regulation of lipid and glucose metabolism in metabolic tissues. These highlights of recent findings are aimed toward advancing our understanding of the role of SCD1 in the development of metabolic diseases, which may help evaluate the possible health outcomes of modulating MUFA levels through targeting SCD1 activity.

PMID:
29089222
PMCID:
PMC5701860
[Available on 2018-12-01]
DOI:
10.1016/j.tem.2017.10.003
[Indexed for MEDLINE]

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