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BMC Biol. 2017 Oct 31;15(1):102. doi: 10.1186/s12915-017-0432-0.

Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers.

Author information

1
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK. c.stefan@ucl.ac.uk.
2
Cell Biology Program, The Hospital for Sick Children and Department of Biochemistry, University of Toronto, Toronto, Canada. wtrimble@sickkids.ca.
3
Cell Biology Program, The Hospital for Sick Children and Department of Biochemistry, University of Toronto, Toronto, Canada. sergio.grinstein@sickkids.ca.
4
Université Côte d'Azur, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France. drin@ipmc.cnrs.fr.
5
Department of Cell Biology, Yale University School of Medicine, New Haven, CT, 06520, USA. karin.reinisch@yale.edu.
6
Department of Neuroscience and Cell Biology, Howard Hughes Medical Institute, Kavli Institute for Neuroscience and Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, 06510, USA. pietro.decamilli@yale.edu.
7
NICHD, NIH, Bethesda, MD, USA.
8
HHMI Janelia Research Campus, Ashburn, VA, USA. lippincottschwartzj@janelia.hhmi.org.
9
UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK. tim.levine@ucl.ac.uk.
10
Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA.
11
Department of Biochemistry, Weill Cornell Medical College, 1300 York Ave, New York, NY, 10065, USA. frmaxfie@med.cornell.edu.
12
UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK. c.futter@ucl.ac.uk.
13
UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK. e.eden@ucl.ac.uk.
14
Molecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute, London, UK.
15
Laboratory of Cell Death Research and Therapy, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
16
Molecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute, London, UK. sharon.tooze@crick.ac.uk.
17
Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
18
Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec, H3A 2B4, Canada. heidi.mcbride@mcgill.ca.

Abstract

Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and organelle biogenesis continue to be a puzzle. This is because lipids flow from many sources and across many paths via transport vesicles, non-vesicular transfer proteins, and dynamic interactions between organelles at membrane contact sites. This forum presents our latest understanding, appreciation, and queries regarding the lipid transport mechanisms necessary to drive membrane expansion during organelle biogenesis and cell growth.

PMID:
29089042
PMCID:
PMC5663033
DOI:
10.1186/s12915-017-0432-0
[Indexed for MEDLINE]
Free PMC Article

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