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Cardiovasc Res. 2017 Nov 1;113(13):1538-1550. doi: 10.1093/cvr/cvx130.

Insights into innate immune signalling in controlling cardiac remodelling.

Zhang Y1,2,3, Huang Z1,2,3,4, Li H1,2,3.

Author information

1
Department of Cardiology, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuchang District, Wuhan 430060, People's Republic of China.
2
Institute of Model Animal of Wuhan University, Donghu Road 115, Wuchang District, Wuhan 430071, People's Republic of China.
3
Medical Research Institute, School of Medicine, Wuhan University, Donghu Road 115, Wuchang District, Wuhan 430071, People's Republic of China.
4
College of Life Sciences, Wuhan University, Wuhan 430072, People's Republic of China.

Abstract

Canonical innate immune signalling involves complex cascades: multiple germline-encoded pattern recognition receptors rapidly recognize pathogen-associated or damage-associated molecular patterns to induce the production of cytokines, which bind to their corresponding receptors to orchestrate subsequent host defense phases. Inflammation is a healthy response to pathogenic signals, which are typically rapid and specific, and they terminate once the threat has passed. However, excessive activation or suppression of innate immune or inflammatory responses can lead to considerable human suffering, such as cardiac remodelling. Interestingly, recent studies have revealed that innate immune molecules in the parenchymal cells of the heart influence cardiac homeostasis not only by directly regulating innate immune responses but also through reprogrammed signalling pathways, which are independent of conventional innate immune signalling. Elucidating 'innate immune signalling reprogramming' events will help us better understand the functions of innate immune molecules and, moreover, the pathogenesis of cardiac diseases.

KEYWORDS:

Hypertensive ventricular remodelling; Innate immune signalling; Ischaemic heart disease; Reprogramming

PMID:
29088374
DOI:
10.1093/cvr/cvx130
[Indexed for MEDLINE]

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