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Ann Biomed Eng. 2018 Jan;46(1):186-196. doi: 10.1007/s10439-017-1940-3. Epub 2017 Oct 30.

Role of Re-entry Tears on the Dynamics of Type B Dissection Flap.

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California Medical Innovations Institute, 11107 Roselle St., Rm. 211, San Diego, CA, 92121, USA.
3DT holdings LLC, San Diego, CA, USA.
Cook Medical Inc, Bloomington, IN, USA.
Aortic Center, Hôpital Cardiologique, CHU de Lille, Lille, France.
California Medical Innovations Institute, 11107 Roselle St., Rm. 211, San Diego, CA, 92121, USA.


Mortality during follow-up after acute Type B aortic dissection is substantial with aortic expansion observed in over 59% of the patients. Lumen pressure differential is considered a prime contributing factor for aortic dilation after propagation. The objective of the study was to evaluate the relationship between changes in vessel geometry with and without lumen pressure differential post propagation in an ex vivo porcine model with comparison with patient clinical data. A pulse duplicator system was utilized to propagate the dissection within descending thoracic porcine aortic vessels for set proximal (%circumference of the entry tear: 40%, axial length: 2 cm) and re-entry (50% of distal vessel circumference) tear geometry. Measurements of lumen pressure differential were made along with quantification of vessel geometry (n = 16). The magnitude of mean lumen pressure difference measured after propagation was low (~ 5 mmHg) with higher pressures measured in false lumen and as anticipated the pressure difference approached zero after the creation of distal re-entry tear. False lumen Dissection Ratio (FDR) defined as arc length of dissected wall divided by arc length of dissection flap, had mean value of 1.59 ± 0.01 at pressure of 120/80 mmHg post propagation with increasing values with increase in pulse pressure that was not rescued with the creation of distal re-entry tear (p < 0.01). An average FDR of 1.87 ± 0.27 was measured in patients with acute Type B dissection. Higher FDR value (FDR = 1 implies zero dissection) in the presence of distal re-entry tear demonstrates an acute change in vessel morphology in response to the dissection independent of local pressure changes challenges the re-apposition of the aortic wall.


Acute aortic dissection; Clinical FDR; Dilation; Ex vivo model; Lumen pressure; Strain

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