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Iran J Basic Med Sci. 2017 Aug;20(8):841-848. doi: 10.22038/IJBMS.2017.9104.

Potential fluoride toxicity from oral medicaments: A review.

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Department of Oral Biology, Sindh Institute of Oral Health Sciences Jinnah Sindh Medical University, Karachi, Pakistan.
Department of Restorative Dentistry, College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Saudi Arabia.
Department of Dental Materials, Islamic International Dental College, Riphah International University, Islamabad, Pakistan.


The beneficial effects of fluoride on human oral health are well studied. There are numerous studies demonstrating that a small amount of fluoride delivered to the oral cavity decreases the prevalence of dental decay and results in stronger teeth and bones. However, ingestion of fluoride more than the recommended limit leads to toxicity and adverse effects. In order to update our understanding of fluoride and its potential toxicity, we have described the mechanisms of fluoride metabolism, toxic effects, and management of fluoride toxicity. The main aim of this review is to highlight the potential adverse effects of fluoride overdose and poorly understood toxicity. In addition, the related clinical significance of fluoride overdose and toxicity has been discussed.


Fluoridation; Fluoride; Oral health; Toxicity; Water fluoridation

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