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Stem Cells Int. 2017;2017:7012405. doi: 10.1155/2017/7012405. Epub 2017 Sep 20.

BMP4/LIF or RA/Forskolin Suppresses the Proliferation of Neural Stem Cells Derived from Adult Monkey Brain.

Author information

1
Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, China.
2
School of Medicine, Jiaxing University, Zhejiang 314001, China.
3
Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200092, China.
4
Changzheng Hospital, Second Hospital Affiliated with Second Military Medical University, Shanghai 200003, China.
5
Tongji University Advanced Institute of Translational Medicine, Shanghai 200092, China.

Abstract

Monkeys are much closer to human and are the most common nonhuman primates which are used in biomedical studies. Neural progenitor cells can originate from the hippocampus of adult monkeys. Despite a few reports, the detailed properties of monkey neural stem cells (NSCs) and their responses to cytokine are still unclear. Here, we derive NSCs from an adult monkey brain and demonstrate that BMP4 inhibits cell proliferation and affects cell morphology of monkey NSCs. Combined treatment of BMP4 and LIF or RA and Forskolin represses the proliferation of monkey NSCs. We also show that BMP4 may promote monkey NSC quiescence. Our study therefore provides implications for NSC-based cell therapy of brain injury in the future.

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