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World J Gastroenterol. 2017 Sep 21;23(35):6412-6419. doi: 10.3748/wjg.v23.i35.6412.

Effects of aspirin and enoxaparin in a rat model of liver fibrosis.

Author information

1
Department of Gastroenterology, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China. chenjielimao@126.com.
2
Department of Medicine, Hospital of National University of Defense Technology, Changsha 410073, Hunan Province, China.
3
Department of Gastroenterology, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China.

Abstract

AIM:

To examine the effects of aspirin and enoxaparin on liver function, coagulation index and histopathology in a rat model of liver fibrosis. METHODS Forty-five male Sprague-Dawley rats were randomly divided into the control group (n = 5) and model group (n = 40). Thioacetamide (TAA) was used to induce liver fibrosis in the model group. TAA-induced fibrotic rats received TAA continuously (n = 9), TAA + low-dose aspirin (n = 9), TAA + high-dose aspirin (n = 9) or TAA + enoxaparin (n = 9) for 4 wk. All rats were euthanized after 4 wk, and both hematoxylin-eosin and Masson staining were performed to observe pathological changes in liver tissue.

RESULTS:

Liver fibrosis was assessed according to the METAVIR score. Compared with untreated cirrhotic controls, a significant improvement in fibrosis grade was observed in the low-dose aspirin, high-dose aspirin and enoxaparin treated groups, especially in the high-dose aspirin treated group. Alanine aminotransferase and total bilirubin were higher, albumin was lower and both prothrombin time and international normalized ratio were prolonged in the four treatment groups compared to controls. No significant differences among the four groups were observed.

CONCLUSION:

Aspirin and enoxaparin can alleviate liver fibrosis in this rat model.

KEYWORDS:

Aspirin; Enoxaparin; Liver fibrosis; Rat; Thioacetamide

PMID:
29085190
PMCID:
PMC5643266
DOI:
10.3748/wjg.v23.i35.6412
[Indexed for MEDLINE]
Free PMC Article

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