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Sci Rep. 2017 Oct 30;7(1):14362. doi: 10.1038/s41598-017-13195-5.

Comparative metabolomics study on therapeutic mechanism of electro-acupuncture and moxibustion on rats with chronic atrophic gastritis (CAG).

Author information

1
Department of Traditional Chinese Medicine and Shenzhen Research Institute, Xiamen University, Xiamen, 361005, China.
2
College of Acupuncture and Moxibustion, Fujian university of Traditional Chinese Medicine, Fuzhou, 350122, China.
3
College of Acupuncture and Moxibustion, Hunan university of Traditional Chinese Medicine, Changsha, 410208, China.
4
School of Life Sciences, Xiamen University, Xiamen, 361005, China.
5
Department of Traditional Chinese Medicine and Shenzhen Research Institute, Xiamen University, Xiamen, 361005, China. yangzb@xmu.edu.cn.

Abstract

Some studies have proved that both acupuncture and moxibustion are very effective for the treatment of CAG. However, little is known about therapeutic mechanism of electro-acupuncture and moxibustion on CAG as well as the difference between them. On the other hand, metabolomics is a 'top-down' approach to understand metabolic changes of organisms caused by disease or interventions in holistic context, which consists with the holistic thinking of electro-acupuncture and moxibustion treatment. In this study, the difference of therapeutic mechanism between electro-acupuncture and moxibustion on CAG rats was investigated by a 1H NMR-based metabolomics analysis of multiple biological samples (serum, stomach, cerebral cortex and medulla) coupled with pathological examination and molecular biological assay. For all sample types, both electro-acupuncture and moxibustion intervention showed beneficial effects by restoring many CAG-induced metabolic changes involved in membrane metabolism, energy metabolism and function of neurotransmitters. Notably, the moxibustion played an important role in CAG treatment mainly by regulating energy metabolism in serum, while main acting site of electro-acupuncture treatment was nervous system in stomach and brain. These findings are helpful to facilitate the therapeutic mechanism elucidating of electro-acupuncture and moxibustion on CAG rats. Metabolomics is promising in mechanisms study for traditional Chinese medicine (TCM).

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