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Genome Biol. 2017 Oct 30;18(1):205. doi: 10.1186/s13059-017-1347-3.

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs.

Author information

1
St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia. cwalkley@svi.edu.au.
2
Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, 3065, Australia. cwalkley@svi.edu.au.
3
Department of Genetics, Stanford University, Stanford, CA, 94305, USA. jin.billy.li@stanford.edu.

Abstract

One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The functional requirement and regulatory landscape for the majority of A-to-I editing events are, at present, uncertain. Recent studies have identified key in vivo functions of ADAR enzymes, informing our understanding of the biological importance of A-to-I editing. Large-scale studies have revealed how editing is regulated both in cis and in trans. This review will explore these recent studies and how they broaden our understanding of the functions and regulation of ADAR-mediated RNA editing.

PMID:
29084589
PMCID:
PMC5663115
DOI:
10.1186/s13059-017-1347-3
[Indexed for MEDLINE]
Free PMC Article

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