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J Agric Food Chem. 2017 Nov 22;65(46):10011-10019. doi: 10.1021/acs.jafc.7b03764. Epub 2017 Nov 8.

Antiobesity Effect of Exopolysaccharides Isolated from Kefir Grains.

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Department of Food and Nutrition, Hanyang University , Seoul 04763, Republic of Korea.
Western Research Center, United States Department of Agriculture , Albany, California 94710, United States.
Center for One Health, College of Veterinary Medicine, Konkuk University , Seoul 05029, Republic of Korea.


Physiological properties of water-soluble exopolysaccharides (EPS) and residues after EPS removal (Res) from the probiotic kefir were determined in high-fat (HF) diet-fed C57BL/6J mice. EPS solutions showed rheological properties and lower viscosity compared to those of β-glucan (BG). EPS significantly suppressed the adipogenesis of 3T3-L1 preadipocytes in a dose-dependent manner. Mice were fed HF diets containing 5% EPS, 5% BG, 8% Res, or 5% microcrystalline cellulose (control) for 4 weeks. Compared with the control, EPS supplementation significantly reduced HF diet-induced body weight gain, adipose tissue weight, and plasma very-low-density lipoprotein cholesterol concentration (P < 0.05). Res and BG significantly reduced body weight gain; however, reduction in adipose tissue weight was not statistically significant, suggesting that the antiobesity effect of EPS occurs due to viscosity and an additional factor. EPS supplementation significantly enhanced abundance of Akkermansia spp. in feces. These data indicate that EPS shows significant antiobesity effects possibly via intestinal microbiota alterations.


Akkermansia; exopolysaccharides; intestinal microbiota; obesity; β-glucan

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