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Appl Immunohistochem Mol Morphol. 2018 Mar;26(3):192-197. doi: 10.1097/PAI.0000000000000410.

Renal Cell Carcinoma With Leiomyomatous Stroma: A Group of Tumors With Indistinguishable Histopathologic Features, But 2 Distinct Genetic Profiles: Next-Generation Sequencing Analysis of 6 Cases Negative for Aberrations Related to the VHL gene.

Author information

1
Department of Pathology, National University Health System Hospital, Singapore, Singapore.
2
Departments of Pathology.
3
Department of Pathology, Institute Nacional de Cancerologia, Mexico City, Mexico.
4
Department of Pathology, University of Sarajevo, Sarajevo, Bosnia, and Hercegovina.
5
Department of Pathology, University Hospital Sestre Milosrdnice, Zagreb, Croatia.
6
Department of Pathology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
7
Urology.
8
Oncology, Charles University, Medical Faculty and Charles University Hospital Plzen, Plzen.

Abstract

We have studied a cohort of renal cell carcinomas (RCCs) with smooth-muscle stroma (N=6), which lacked any of following genetic aberrations: mutations in the VHL-gene-coding sequence, loss of heterozygosity of chromosome 3p, or hypermethylation of VHL. Using targeted next-generation sequencing, no intronic VHL mutations or mutations in selected genes involved in angiogenesis and genes frequently mutated in clear cell RCC were identified. Tumors were also tested for the presence of hotspot mutations in the TCEB1 gene with negative results in all cases. We conclude that there exists a group of RCCs with abundant leiomyomatous stroma, where the epithelial component is indistinguishable from conventional clear cell RCC and distinct from clear cell (tubulo-) papillary RCC and that these tumors lack aberrations related to the function of the VHL gene, mutations in genes involved in angiogenesis, and hotspot mutations in the TCEB1 gene.

PMID:
29084058
DOI:
10.1097/PAI.0000000000000410
[Indexed for MEDLINE]

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