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Kayser-Fleischer Ring.


Pandey N1, John S2.


StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018-.
2018 Oct 27.

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MaxSuperSpecialty Hospital Saket India
SUNY Upstate Medical University


Kayser–Fleischer (KF) rings are a common ophthalmologic finding in patients with Wilson disease. Initially thought to be due to the accumulation of silver, they were first demonstrated to contain copper in 1934. KF rings are seen in most of the patients with neurologic involvement from Wilson disease. These rings are caused by deposition of excess copper on the inner surface of the cornea in the Descemet membrane. A slit lamp examination is mandatory to make a diagnosis of KF rings particulalrly in the eraly stages, unless the rings are visible to the naked eye in conditions of severe copper overload. Kayser–Fleischer rings do not cause any impairment of vision but disappear with treatment and reappear with disease progression. KF rings not specific to Wilson disease alone, they are also seen in other chronic cholestatic disorders such as primary biliary cholangitis and children with neonatal cholestasis.

Copyright © 2018, StatPearls Publishing LLC.

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