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Org Biomol Chem. 2017 Nov 15;15(44):9311-9318. doi: 10.1039/c7ob02014g.

A Cu(ii)-promoted tandem decarboxylative halogenation and oxidative diamination reaction of 2-aminopyridines with alkynoic acids for the synthesis of 2-haloimidazo[1,2-a]pyridines.

Author information

1
Jiangsu Key Laboratory of Green Synthesis for Functional Materials and School of Chemistry and Material Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu, P. R. China. liu__yun3@sina.com.

Abstract

A copper-promoted cascade decarboxylative halogenation and oxidative diamination reaction sequence of 2-aminopyridines with alkynoic acids has been developed for the synthesis of 2-haloimidazo[1,2-a]pyridines. In this reaction, two C-N bonds and one C-halogen bond are formed in one pot, generating the desired products in good yields. This is the first report on the synthesis of 2-haloimidazo[1,2-a]pyridine derivatives from alkynoic acids.

PMID:
29083000
DOI:
10.1039/c7ob02014g

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