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Chem Commun (Camb). 2017 Nov 16;53(92):12430-12433. doi: 10.1039/c7cc06866b.

Catalytic transient leaving group for atom-economic synthesis of allenes from 2-alkynols.

Author information

1
Shanghai Key Laboratory of Green Chemistry and Chemical Process, College of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Lu, Shanghai, 200062, P. R. China.

Abstract

An atom economic approach from readily available propargylic alcohols to allenes, the first carboxylation of propargylic alcohols, has been established. Through the cooperative binary catalysis of Pd and a phosphoric acid, the reaction afforded multi-substituted allenoates with a broad scope tolerating useful functional groups. The synthetic potential of the obtained products has been demonstrated.

PMID:
29082989
DOI:
10.1039/c7cc06866b

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