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Can J Infect Dis Med Microbiol. 2017;2017:1671607. doi: 10.1155/2017/1671607. Epub 2017 Sep 7.

Roles of Interferons in Pregnant Women with Dengue Infection: Protective or Dangerous Factors.

Author information

1
Department of Infectious Diseases, The Key Discipline of Guangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, No. 151 Yanjiang Road, Guangdong Province 510120, China.
2
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, No. 151 Yanjiang Road, Guangdong Province 510120, China.
3
Guangdong Provincial Key Laboratory of Tropical Disease Research and Key Laboratory of Prevention and Control for Emerging Infectious Diseases of Guangdong Higher Institutes, School of Public Health and Tropical Medicine, Southern Medical University, No. 1023 South Shatai Road, Guangzhou, Guangdong Province 510515, China.

Abstract

Dengue infection is a serious public health problem in tropical and subtropical areas. With the recent outbreaks of Zika disease and its reported correlation with microcephaly, the large number of pregnancies with dengue infection has become a serious concern. This review describes the epidemiological characteristics of pregnancy with dengue and the initial immune response to dengue infection, especially in IFNs production in this group of patients. Dengue is much more prevalent in pregnant women compared with other populations. The severity of dengue is correlated with the level of IFNs, while the serum IFN level must be sufficiently high to maintain the pregnancy and to inhibit virus replication.

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