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Int J Infect Dis. 2017 Dec;65:107-109. doi: 10.1016/j.ijid.2017.10.011. Epub 2017 Nov 10.

Central nervous system infections in the absence of cerebrospinal fluid pleocytosis.

Author information

1
Department of Infectious Diseases and Clinical Microbiology, Gulhane Medical Academy, Ankara, Turkey.
2
Department of Infectious Diseases and Clinical Microbiology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
3
Department of Infectious Diseases and Clinical Microbiology, Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey.
4
Department of Infectious Diseases and Clinical Microbiology, Uludag University School of Medicine, Bursa, Turkey.
5
Department of Infectious Diseases and Clinical Microbiology, Cumhuriyet University School of Medicine, Sivas, Turkey.
6
Department of Infectious Diseases and Clinical Microbiology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey.
7
Department of Infectious Diseases, UT Health McGovern Medical School, Houston, TX, USA. Electronic address: Rodrigo.Hasbun@uth.tmc.edu.

Abstract

Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated.

KEYWORDS:

CSF; Encephalitis; Leukocyte; Meningitis; Pleocytosis

PMID:
29081366
DOI:
10.1016/j.ijid.2017.10.011
[Indexed for MEDLINE]
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