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J Microbiol Biotechnol. 2018 Jan 28;28(1):175-179. doi: 10.4014/jmb.1709.09042.

Lactobacillus plantarum C29 Alleviates TNBS-Induced Memory Impairment in Mice.

Author information

1
Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
2
Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Republic of Korea.

Abstract

In a preliminary study, Lactobacillus plantarum C29 was found to suppress 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Therefore, to understand whether an anti-colitic probiotic C29 could attenuate memory impairment, we examined the effects of C29 on TNBS-induced memory impairment in mice. Orally administered Lactobacillus plantarum C29 attenuated TNBS-induced memory impairment in mice in the Y-maze, noble object, and passive avoidance task tests. C29 treatment increased TNBS-suppressed hippocampal brain-derived neurotrophic factor expression and inhibited TNBS-induced hippocampal NF-kappaB activation and blood LPS levels. Moreover, C29 restored the TNBS-disturbed gut microbiota composition. These findings suggest that C29 can alleviate memory impairment presumably by restoring the gut microbiota composition.

KEYWORDS:

Lactobacillus plantarum; colitis; gut microbiota; memory impairment

PMID:
29081213
DOI:
10.4014/jmb.1709.09042
[Indexed for MEDLINE]
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