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Endocrinol Metab Clin North Am. 2017 Dec;46(4):815-843. doi: 10.1016/j.ecl.2017.07.001. Epub 2017 Sep 29.

Biology and Mechanisms of Action of the Vitamin D Hormone.

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Department of Biochemistry, University of Wisconsin-Madison, Biochem Addition, Room 543D, 433 Babcock Drive, Madison, WI 53706, USA. Electronic address:
Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA.


The central role of hormonal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is to regulate calcium and phosphorus homeostasis via actions in intestine, kidney, and bone. These and other actions in many cell types not involved in mineral metabolism are mediated by the vitamin D receptor. Recent studies using genome-wide scale techniques have extended fundamental ideas regarding vitamin D-mediated control of gene expression while simultaneously revealing a series of new concepts. This article summarizes the current view of the biological actions of the vitamin D hormone and focuses on new concepts that drive the understanding of the mechanisms through which vitamin D operates.


Calcemic hormones; Genetic linkage; Genome-wide principles; Mineral homeostasis; RANKL; Target genes; Transcription; Transient receptor potential vanilloid type-6 (TRPV6)

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