Format

Send to

Choose Destination
Endocrinol Metab Clin North Am. 2017 Dec;46(4):1039-1059. doi: 10.1016/j.ecl.2017.07.009. Epub 2017 Sep 29.

Role of Vitamin D in Cardiovascular Diseases.

Author information

1
Department of Clinical and Translational Science, Creighton University School of Medicine, CRISS II Room 510, 2500 California Plaza, Omaha, NE 68178, USA.
2
Department of Clinical and Translational Science, Creighton University School of Medicine, CRISS II Room 510, 2500 California Plaza, Omaha, NE 68178, USA. Electronic address: dkagr@creighton.edu.

Abstract

Vitamin D is critical in mineral homeostasis and skeletal health and plays a regulatory role in nonskeletal tissues. Vitamin D deficiency is associated with chronic inflammatory diseases, including diabetes and obesity, both strong risk factors for cardiovascular diseases (CVDs). CVDs, including coronary artery disease, myocardial infarction, hypertrophy, cardiomyopathy, cardiac fibrosis, heart failure, aneurysm, peripheral arterial disease, hypertension, and atherosclerosis, are major causes of morbidity and mortality. The association of these diseases with vitamin D deficiency and improvement with vitamin D supplementation suggest its therapeutic benefit. The authors review the findings on the association of vitamin D deficiency and CVDs.

KEYWORDS:

Atherosclerosis; Cardiac failure and fibrosis; Cardiomyopathy; Cardiovascular disease; Left ventricular hypertrophy; Myocardial infarction; Peripheral vascular disease; Vitamin D deficiency

PMID:
29080634
PMCID:
PMC5675035
DOI:
10.1016/j.ecl.2017.07.009
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center