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Cell Tissue Res. 2018 Jan;371(1):91-103. doi: 10.1007/s00441-017-2708-7. Epub 2017 Oct 27.

SoxC transcription factors: multifunctional regulators of neurodevelopment.

Author information

1
Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.
2
Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany. chi.lie@fau.de.

Abstract

During development, generation of neurons is coordinated by the sequential activation of gene expression programs by stage- and subtype-specific transcription factor networks. The SoxC group transcription factors, Sox4 and Sox11, have recently emerged as critical components of this network. Initially identified as survival and differentiation factors for neural precursors, SoxC factors have now been linked to a broader array of developmental processes including neuronal subtype specification, migration, dendritogenesis and establishment of neuronal projections, and are now being employed in experimental strategies for neuronal replacement and axonal regeneration in the diseased central nervous system. This review summarizes the current knowledge regarding SoxC factor function in CNS development and disease and their promise for regeneration.

KEYWORDS:

Neurogenesis; Regeneration; Reprogramming; Sox11; Sox4; Transcription factor

PMID:
29079881
DOI:
10.1007/s00441-017-2708-7
[Indexed for MEDLINE]

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