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Clin Nucl Med. 2018 Jan;43(1):28-30. doi: 10.1097/RLU.0000000000001883.

Intracardiac Metastases Detected by 18F-FSPG PET/CT.

Abstract

PET/CT imaging is frequently used for cancer diagnosis and restaging as metabolically active cells, including cancer, utilize glucose for proliferation. F-FDG is the most commonly utilized radiopharmaceutical in PET/CT imaging. Limitations of F-FDG imaging include intense physiologic uptake in benign tissues such as the brain and myocardium. We present a case of non-small cell lung cancer with myocardial and pericardial metastases obscured by physiologic F-FDG cardiac uptake but detected with the investigational PET radiotracer (4S)-4-(3-F-fluoropropyl)-L-glutamate (F-FSPG), which targets a pathway associated with glutathione biosynthesis. This case demonstrates the added value of F-FSPG PET/CT imaging.

PMID:
29076915
PMCID:
PMC5716866
DOI:
10.1097/RLU.0000000000001883
[Indexed for MEDLINE]
Free PMC Article

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