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Cancer Med. 2017 Dec;6(12):2757-2765. doi: 10.1002/cam4.1163. Epub 2017 Oct 26.

Prognostic significance of postoperative pneumonia after curative resection for patients with gastric cancer.

Tu RH1,2, Lin JX1,2, Li P1,2, Xie JW1,2, Wang JB1,2, Lu J1,2, Chen QY1,2, Cao LL1,2, Lin M1,2, Zheng CH1,2,3,4, Huang CM1,2,3,4.

Author information

1
Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
2
Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
3
Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
4
Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China.

Abstract

Few studies have been designed to investigate the incidence of postoperative pneumonia after radical gastrectomy and its effect on prognosis of these patients. Incidences of postoperative pneumonia after radical gastrectomy in our department between January 1996 and December 2014 were summarized. Their effects on prognosis were retrospectively analyzed using survival curves and Cox regression. A total of 5237 patients were included in this study, 767 (14.4%) of them had complications, including 383 cases of postoperative pneumonia (7.2%). The 5-year overall and disease-specific survival of patients with postoperative pneumonia were both lower than those without this complication (P < 0.001). Stratified analysis demonstrated that this difference existed in all Stage I, II, and III patients (log-rank, P < 0.05). Multivariate analysis revealed that age, neoadjuvant chemotherapy, tumor size, tumor stage, and postoperative pneumonia were independent risk factors for disease-specific survival. Postoperative pneumonia after radical gastrectomy is an independent risk factor for prognosis of gastric cancer patients, especially in stage III.

KEYWORDS:

Complications; gastrectomy; prognosis; stomach cancer

PMID:
29076260
PMCID:
PMC5727328
DOI:
10.1002/cam4.1163
[Indexed for MEDLINE]
Free PMC Article

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