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AIDS Behav. 2018 Mar;22(3):986-995. doi: 10.1007/s10461-017-1955-7.

Brief Participant-Centered Convergence Interviews Integrate Self-Reports, Product Returns, and Pharmacokinetic Results to Improve Adherence Measurement in MTN-017.

Author information

1
HIV Center for Clinical and Behavioral Studies at New York State Psychiatric Institute and Columbia University, Unit 15, 1051 Riverside Drive, New York, NY, 10032, USA. balaniv@nyspi.columbia.edu.
2
HIV Center for Clinical and Behavioral Studies at New York State Psychiatric Institute and Columbia University, Unit 15, 1051 Riverside Drive, New York, NY, 10032, USA.
3
Department of Medicine, Center for AIDS Prevention Studies, University of California San Francisco, San Francisco, CA, USA.
4
FHI 360, Durham, NC, USA.
5
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
6
Magee-Womens Research Institute, Pittsburgh, PA, USA.
7
Statistical Center for HIV/AIDS Research & Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
8
Division of AIDS, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA.
9
School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
10
Asociación Civil Impacta Salud y Educación, Lima, Peru.

Abstract

MTN-017 compared the safety and acceptability of daily oral emtricitabine/tenofovir disoproxil fumarate, daily reduced-glycerin 1% tenofovir gel applied rectally, and the same gel applied before and after receptive anal intercourse. The Data Convergence Interview (DCI) and the Pharmacokinetic Data Convergence Interview (PK-DCI) were brief, collaborative interactions conducted with participants during adherence counseling sessions to improve accurate measurement of adherence to study product use. DCIs converged data from product return counts and participants' responses to daily text messages. PK-DCIs, conducted 4 weeks later, converged results of the DCI with PK from the corresponding period. CIs were easily incorporated into adherence counseling sessions, increased the accuracy of adherence data, and provided valuable context to data on product use. Participants were readily engaged in the interviews but, if they felt confronted, provided more guarded responses. As such, how these CIs are conducted is critical to engage participants, even those with poor adherence, to openly discuss challenges with product use.

KEYWORDS:

Adherence; Biomarker; Client-centered counseling; Data accuracy

PMID:
29076032
PMCID:
PMC5983888
DOI:
10.1007/s10461-017-1955-7
[Indexed for MEDLINE]
Free PMC Article

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