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Can J Ophthalmol. 2017 Nov;52 Suppl 1:S39-S44. doi: 10.1016/j.jcjo.2017.09.026.

Relationship between vitamin D deficiency and diabetic retinopathy: a meta-analysis.

Author information

1
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT.
2
Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY; Department of Preventive and Social Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.. Electronic address: Sikarin.Upala@bassett.org.
3
Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY; Department of Preventive and Social Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Abstract

OBJECTIVE:

The purpose of this study was to evaluate the evidence for an association between diabetic retinopathy (DR) and vitamin D deficiency.

DESIGN:

Meta-analysis.

METHODS:

We included 14 observational studies with 10 007 participants who had undergone assessment for both DR and vitamin D deficiency. Pooled odds ratios (ORs) and 95% CIs were calculated using a random-effect, Mantel-Haenszel analysis.

RESULTS:

There was a statistically significant association between DR and vitamin D deficiency with an overall pooled OR of 1.27 (95% CI, 1.17-1.37; P = 0.001; I2 = 80%; Pheterogeneity = 0.01). There was also a statistically significant lower serum vitamin D level in patient subgroups with DR versus control groups, with an overall mean difference of -1.32 ng/mL (95% CI, -2.50 to -0.15; P = 0.001; I2 = 89%; Pheterogeneity = 0.01).

CONCLUSION:

There is a statistically significant association between vitamin D deficiency and DR.

PMID:
29074012
DOI:
10.1016/j.jcjo.2017.09.026
[Indexed for MEDLINE]

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