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Nat Neurosci. 2017 Oct 26;20(11):1483-1492. doi: 10.1038/nn.4652. [Epub ahead of print]

Synaptic integrative mechanisms for spatial cognition.

Author information

1
Institut Pasteur, Paris, France.
2
Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.

Abstract

Synaptic integrative mechanisms have profound effects on electrical signaling in the brain that, although largely hidden from recording methods that observe the spiking activity of neurons, may be critical for the encoding, storage and retrieval of information. Here we review roles for synaptic integrative mechanisms in the selection, generation and plasticity of place and grid fields, and in related temporal codes for the representation of space. We outline outstanding questions and challenges in the testing of hypothesized models for spatial computation and memory.

PMID:
29073648
DOI:
10.1038/nn.4652

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