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Gait Posture. 2018 Jan;59:193-198. doi: 10.1016/j.gaitpost.2017.09.032. Epub 2017 Oct 16.

Prefrontal cortex activation during a dual task in patients with stroke.

Author information

1
Department of Physical Medicine and Rehabilitation, Tohoku University Graduates School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai, 980-8575, Japan. Electronic address: t-mori@med.tohoku.ac.jp.
2
Department of Physical Medicine and Rehabilitation, Tohoku University Graduates School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai, 980-8575, Japan. Electronic address: naoyuki@med.hokudai.ac.jp.
3
Department of Physical Medicine and Rehabilitation, Tohoku University Graduates School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai, 980-8575, Japan; Tohoku University Graduate School of Biomedical Engineering, 2-1 Seiryo-cho, Aoba-ku, Sendai, 980-8575, Japan. Electronic address: izumis@med.tohoku.ac.jp.

Abstract

Dual tasks destabilize task performance as they involve competing demands for cognitive and physical resources. Several studies have reported that dual-task walking activates the prefrontal cortex (PFC), and recent studies have indicated a relationship between PFC and dual-task deterioration in healthy subjects. However, PFC activity during dual-task walking in stroke patients remains unclear. We investigated the association between PFC activity and dual-task interference on physical and cognitive performance in stroke patients. This study included 14 stroke patients and 14 healthy subjects who performed a calculation task while walking at a comfortable pace on the floor. PFC activity was assessed using wearable near-infrared spectroscopy. The calculation task and trunk linear accelerations were evaluated as measures of cognitive and physical performance. The dual-task deterioration on both physical and cognitive performance of stroke patients was significantly higher than in healthy subjects. PFC activation during dual-task walking was significantly lower in stroke patients. Although right PFC activation was negatively correlated with dual-task deterioration on physical performance in stroke patients, left PFC activation was negatively correlated with the dual-task cost on cognitive performance in healthy subjects. Thus, during dual-task walking, PFC activation might prioritize physical demands in stroke patients, but might prioritize cognitive demands in healthy subjects.

KEYWORDS:

Dual task; Gait stability; Near-infrared spectroscopy; Prioritization; Stroke

PMID:
29073516
DOI:
10.1016/j.gaitpost.2017.09.032
[Indexed for MEDLINE]

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