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Nanomaterials (Basel). 2017 Oct 26;7(11). pii: E351. doi: 10.3390/nano7110351.

Liposome-Coated Iron Fumarate Metal-Organic Framework Nanoparticles for Combination Therapy.

Author information

1
Department of Chemistry and Center for NanoScience (CeNS), LMU Munich, Butenandtstraße 11 (E), 81377 Munich, Germany. bernhard.illes@cup.uni-muenchen.de.
2
Department of Chemistry and Center for NanoScience (CeNS), LMU Munich, Butenandtstraße 11 (E), 81377 Munich, Germany. stefan.wuttke@cup.uni-muenchen.de.
3
School of Chemistry, Joseph Banks Laboratories, University of Lincoln, Lincoln LN67TS, UK. stefan.wuttke@cup.uni-muenchen.de.
4
Department of Chemistry and Center for NanoScience (CeNS), LMU Munich, Butenandtstraße 11 (E), 81377 Munich, Germany. hanna.engelke@cup.lmu.de.

Abstract

One of the main problems for effective treatment of cancer is resistances, which often require combination therapy-for effective treatment. While there are already some potential drug carriers-e.g., liposomes, available for treatment-the effective loading and retention of the desired drug ratio can be challenging. To address this challenge, we propose a new type of drug carrier: liposome-coated metal-organic framework (MOF) nanoparticles. They combine the advantages of liposomes with an easy and efficient loading process. In this work, we present the successful synthesis of liposome-coated MOF nanoparticles via the fusion method. The resulting particles, once loaded, show no premature leakage and an efficient release. Their successful loading with both single and multiple drugs at the same time makes them an interesting candidate for use in combination therapy.

KEYWORDS:

combination therapy; drug delivery; metal-organic framework; nanoparticles

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