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Small GTPases. 2018 Mar 4;9(1-2):76-94. doi: 10.1080/21541248.2017.1353847. Epub 2017 Oct 26.

Rab GTPases in cilium formation and function.

Author information

1
a School of Biomolecular and Biomedical Science , University College Dublin , Belfield, Dublin , Ireland.

Abstract

Cilia are microtubule-based organelles extending from a basal body at the surface of eukaryotic cells. Cilia regulate cell and fluid motility, sensation and developmental signaling, and ciliary defects cause human diseases (ciliopathies) affecting the formation and function of many tissues and organs. Over the past decade, various Rab and Rab-like membrane trafficking proteins have been shown to regulate cilia-related processes such as basal body maturation, ciliary axoneme extension, intraflagellar transport and ciliary signaling. In this review, we provide a comprehensive overview of Rab protein ciliary associations, drawing on findings from multiple model systems, including mammalian cell culture, mice, zebrafish, C. elegans, trypanosomes, and green algae. We also discuss several emerging mechanistic themes related to ciliary Rab cascades and functional redundancy.

KEYWORDS:

Rab GTPases; cilia; ciliary membrane trafficking; ciliopathies; intraflagellar transport

PMID:
29072526
PMCID:
PMC5902210
DOI:
10.1080/21541248.2017.1353847
[Indexed for MEDLINE]
Free PMC Article

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