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Eur Respir Rev. 2017 Oct 25;26(146). pii: 170079. doi: 10.1183/16000617.0079-2017. Print 2017 Dec 31.

Lung segmentectomy: does it offer a real functional benefit over lobectomy?

Author information

1
Physiology and Functional Explorations Dept, University Hospital, Strasbourg, France anne.charloux@chru-strasbourg.fr.
2
EA 3072, Federation of Translational Medicine, Strasbourg University, Strasbourg, France.
3
Pulmonology Dept, University Hospital, Strasbourg, France.

Abstract

Anatomical segmentectomy has been developed to offer better pulmonary function preservation than lobectomy, in stage IA lung cancer. Despite the retrospective nature of most of the studies and the lack of randomised studies, a substantial body of literature today allows us to evaluate to what extent lung function decreases after segmentectomy and whether segmentectomy offers a real functional benefit over lobectomy. From the available series, it emerges that the mean decrease in forced expiratory volume in 1 s (FEV1) is low, ranging from -9% to -24% of the initial value within 2 months and -3 to -13% 12 months after segmentectomy. This reduction in lung function is significantly lower than that induced by lobectomy, but saves only a few per cent of pre-operative FEV1 Moreover, the published results do not firmly establish the functional benefit of segmentectomy over lobectomy in patients with poor lung function. Some issues remain to be addressed, including whether video-assisted thoracic surgery (VATS) segmentectomy may preserve lung function better than VATS lobectomy in patients with poor lung function, especially within the early days after surgery, and whether this may translate to lowering the functional limit for surgery. Eventually, trials comparing stereotactic ablative body radiotherapy, radiofrequency ablation and segmentectomy functional consequences are warranted.

PMID:
29070582
DOI:
10.1183/16000617.0079-2017
[Indexed for MEDLINE]
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