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Infect Dis (Lond). 2018 Mar;50(3):163-174. doi: 10.1080/23744235.2017.1388537. Epub 2017 Oct 26.

Pitfalls in studies of eosinopenia and neutrophil-to-lymphocyte count ratio.

Author information

1
a Resident of Internal Medicine, Second Department of Internal Medicine , General Hospital of Heraklion 'Venizeleio-Pananeio' , Heraklion , Greece.
2
b Resident of General Medicine , University Hospital of Heraklion, Voutes , Heraklion , Greece.
3
c Consultant in Internal Medicine. Second Department of Internal Medicine , General Hospital of Heraklion 'Venizeleio-Pananeio' , Heraklion , Greece.
4
d Head of the Second Department of Internal Medicine , Second Department of Internal Medicine, General Hospital of Heraklion 'Venizeleio-Pananeio' , Heraklion , Greece.

Abstract

There is a number of publications evaluating the eosinophil count and the neutrophil-to-lymphocyte count ratio for diagnosis, prognosis or monitoring of patients. Of special interest is the use of these parameters for discrimination between the different causes of fever (e.g. bacterial versus viral vs. non-infectious causes of fever) and for monitoring the efficacy of therapy and predict the course of the patient. However, pitfalls in previous study designs prevent applicability to clinical practice. Here, we provide a short review of the relevant literature and summarize important factors that should be taken into account when designing studies, with special attention to the selection of a proper and clinically meaningful study population and the effects of the stress response and of corticosteroids.

KEYWORDS:

Eosinopenia; Eosinophil count; Neutrophil-to-lymphocyte count ratio; Pitfalls

PMID:
29070003
DOI:
10.1080/23744235.2017.1388537
[Indexed for MEDLINE]

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