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J Clin Psychopharmacol. 1988 Dec;8(6):417-21.

Psychotic patients who become worse on neuroleptics.

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1
Yale University School of Medicine, Department of Psychiatry, New Haven, Connecticut 06519.

Abstract

We describe a group of psychotic patients who became worse early in the course of neuroleptic treatment. Characteristics of this group were: predominantly female sex, relatively brief onset, family history of affective disorder, hypomotoric presentation, and severe neuroleptic side effects. We propose that some patients with affective psychoses are uniquely susceptible to profound blockade of the nigrostriatal dopaminergic system by neuroleptics.

PMID:
2906948
[Indexed for MEDLINE]
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