Abstract
We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.
Keywords:
Neisseria gonorrhoeae; Resfinder; STD; antibiotic; multidrug-resistant; treatment.
MeSH terms
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Administration, Oral
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use*
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Azithromycin / administration & dosage
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Azithromycin / therapeutic use*
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Ceftriaxone / administration & dosage
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Ceftriaxone / therapeutic use*
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Denmark
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Gonorrhea / drug therapy*
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Gonorrhea / microbiology
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Humans
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Injections, Intramuscular
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Male
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Microbial Sensitivity Tests
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Neisseria gonorrhoeae / drug effects*
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Neisseria gonorrhoeae / genetics
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Neisseria gonorrhoeae / isolation & purification
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Nucleic Acid Amplification Techniques
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Treatment Outcome
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Urethritis / drug therapy
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Urethritis / microbiology
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Young Adult
Substances
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Anti-Bacterial Agents
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Ceftriaxone
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Azithromycin