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Euro Surveill. 2017 Oct;22(42). doi: 10.2807/1560-7917.ES.2017.22.42.17-00659.

Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017.

Author information

1
Department of Clinical Microbiology, Hvidovre Hospital, Copenhagen, Denmark.
2
These authors contributed equally to the work.
3
Department of Dermatovenerology, Bispebjerg Hospital, Copenhagen, Denmark.
4
Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark.
5
WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
6
These authors share last authorship.
7
Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Abstract

We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

KEYWORDS:

Neisseria gonorrhoeae; Resfinder; STD; antibiotic; multidrug-resistant; treatment

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