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Sci Rep. 2017 Oct 24;7(1):13911. doi: 10.1038/s41598-017-14276-1.

Passive and Active Triaxial Wall Mechanics in a Two-Layer Model of Porcine Coronary Artery.

Lu Y1, Wu H2, Li J2, Gong Y1, Ma J3, Kassab GS4, Huo Y5, Tan W6,7,8, Huo Y9,10.

Author information

1
Department of Cardiology, Peking University First Hospital, Beijing, China.
2
Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, China.
3
School of Public Health, Peking University, Beijing, China.
4
California Medical Innovations Institute, San Diego, USA.
5
Department of Cardiology, Peking University First Hospital, Beijing, China. huoyong@263.net.cn.
6
Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, China. tanwch@pku.edu.cn.
7
Shenzhen Graduate School, Peking University, Shenzhen, China. tanwch@pku.edu.cn.
8
PKU-HKUST Shenzhen-Hongkong Institution, Shenzhen, China. tanwch@pku.edu.cn.
9
Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, China. yhuo@pku.edu.cn.
10
PKU-HKUST Shenzhen-Hongkong Institution, Shenzhen, China. yhuo@pku.edu.cn.

Abstract

Triaxial active and passive mechanical properties of coronary arteries are needed for understanding arterial mechanics in health and disease. The aim of the study was to quantify both active and passive strain energy functions in circumferential, axial and radial directions based on the experimental measurement. Moreover, a two-layer computational model was used to determine the transmural distribution of stresses and strains across the vessel wall. The first Piola-Kirchhoff stresses in the three normal directions had the approximate relationship as:[Formula: see text]. The two-layer model showed that circumferential Cauchy stresses increased significantly from the intima layer to the interface between media and adventitia layers (from ~80 to 160 kPa), dropped abruptly at the interface (from ~160 to <5 kPa), and increased slightly towards the outer boundary of the adventitia layer. In contrast, absolute values of radial Cauchy stress decreased continuously from the inner to outer boundaries of the vessel wall (from ~11 kPa to zero). Smooth muscle cell contraction significantly increased the ratio of radial to circumferential Cauchy stresses at the intima-media layer, which had the highest values at the intima layer.

PMID:
29066847
PMCID:
PMC5655692
DOI:
10.1038/s41598-017-14276-1
[Indexed for MEDLINE]
Free PMC Article

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