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J Am Heart Assoc. 2017 Oct 24;6(10). pii: e006802. doi: 10.1161/JAHA.117.006802.

Effect of Monthly, High-Dose, Long-Term Vitamin D Supplementation on Central Blood Pressure Parameters: A Randomized Controlled Trial Substudy.

Author information

1
School of Population Health, University of Auckland, New Zealand j.sluyter@auckland.ac.nz.
2
Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
3
School of Population Health, University of Auckland, New Zealand.
4
Department of General Practice, The University of Otago, Christchurch, New Zealand.
5
Department of Public Health, University of Cambridge, United Kingdom.
6
International Centre for Circulatory Health, Imperial College London, London, United Kingdom.
7
Center for Health & Bioresources, AIT Austrian Institute of Technology, Vienna, Austria.
8
Department of Bioengineering, Imperial College London, London, United Kingdom.
9
Institute of Cardiovascular Sciences, University College London, London, United Kingdom.

Abstract

BACKGROUND:

The effects of monthly, high-dose, long-term (≥1-year) vitamin D supplementation on central blood pressure (BP) parameters are unknown.

METHODS AND RESULTS:

A total of 517 adults (58% male, aged 50-84 years) were recruited into a double-blinded, placebo-controlled trial substudy and randomized to receive, for 1.1 years (median; range: 0.9-1.5 years), either (1) vitamin D3 200 000 IU (initial dose) followed 1 month later by monthly 100 000-IU doses (n=256) or (2) placebo monthly (n=261). At baseline (n=517) and follow-up (n=380), suprasystolic oscillometry was undertaken, yielding aortic BP waveforms and hemodynamic parameters. Mean deseasonalized 25-hydroxyvitamin D increased from 66 nmol/L (SD: 24) at baseline to 122 nmol/L (SD: 42) at follow-up in the vitamin D group, with no change in the placebo group. Despite small, nonsignificant changes in hemodynamic parameters in the total sample (primary outcome), we observed consistently favorable changes among the 150 participants with vitamin D deficiency (<50 nmol/L) at baseline. In this subgroup, mean changes in the vitamin D group (n=71) versus placebo group (n=79) were -5.3 mm Hg (95% confidence interval [CI], -11.8 to 1.3) for brachial systolic BP (P=0.11), -2.8 mm Hg (95% CI, -6.2 to 0.7) for brachial diastolic BP (P=0.12), -7.5 mm Hg (95% CI, -14.4 to -0.6) for aortic systolic BP (P=0.03), -5.7 mm Hg (95% CI, -10.8 to -0.6) for augmentation index (P=0.03), -0.3 m/s (95% CI, -0.6 to -0.1) for pulse wave velocity (P=0.02), -8.6 mm Hg (95% CI, -15.4 to -1.9) for peak reservoir pressure (P=0.01), and -3.6 mm Hg (95% CI, -6.3 to -0.8) for backward pressure amplitude (P=0.01).

CONCLUSIONS:

Monthly, high-dose, 1-year vitamin D supplementation lowered central BP parameters among adults with vitamin D deficiency but not in the total sample.

CLINICAL TRIAL REGISTRATION:

URL: http://www.anzctr.org.au. Unique identifier: ACTRN12611000402943.

KEYWORDS:

arterial stiffness; blood pressure; randomized controlled trial; vitamin D; wave reflection

PMID:
29066444
PMCID:
PMC5721873
DOI:
10.1161/JAHA.117.006802
[Indexed for MEDLINE]
Free PMC Article

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