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Neuropsychologia. 2018 Jul 1;115:5-16. doi: 10.1016/j.neuropsychologia.2017.10.021. Epub 2017 Oct 21.

A hitchhiker's guide to lesion-behaviour mapping.

Author information

1
Center of Neurology, Division of Neuropsychology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. Electronic address: bianca.dehaan@brunel.ac.uk.
2
Center of Neurology, Division of Neuropsychology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; Department of Psychology, University of South Carolina, Columbia, USA.

Abstract

Lesion-behaviour mapping is an influential and popular approach to anatomically localise cognitive brain functions in the human brain. Multiple considerations, ranging from patient selection, assessment of lesion location and patient behaviour, spatial normalisation, statistical testing, to the anatomical interpretation of obtained results, are necessary to optimize a lesion-behaviour mapping study and arrive at meaningful conclusions. Here, we provide a hitchhiker's guide, giving practical guidelines and references for each step of the typical lesion-behaviour mapping study pipeline.

KEYWORDS:

Brain behaviour inference; Human; Lesion analysis; VLBM; VLSM; Voxel based lesion symptom mapping

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