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Nutr Metab Cardiovasc Dis. 2017 Nov;27(11):964-970. doi: 10.1016/j.numecd.2017.09.004. Epub 2017 Sep 21.

Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.

Author information

1
Health Management Institute, Chinese PLA General Hospital, Beijing, China. Electronic address: zq301@126.com.
2
Healthcare Department, Agency for Offices Administration of PLA, Beijing, China.
3
Health Management Center, Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
4
Health Center of Screening and Prevention of Diseases of the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Abstract

BACKGROUND AND AIMS:

Suboptimal health and metabolic disorders are common in the general population. Both are related to cardiovascular disease. Suboptimal cardiovascular health is defined by the presence of both suboptimal health and metabolic disorders. The aim of the study was to investigate the potential benefit of n-3 long-chain polyunsaturated fatty acids (LCPUFA) in participants with suboptimal cardiovascular health.

METHODS AND RESULTS:

A total of 422 participants with suboptimal cardiovascular health, from two clinics in China, were enrolled from September 2014 to April 2015. All the enrolled participants were randomly assigned to receive 4 g/d of fish oil or placebo for three months. Suboptimal health was defined using an accepted questionnaire. Metabolic disorders were defined as one or more abnormalities in blood pressure, fasting plasma glucose, blood lipids, and body mass index (BMI). After treatment, the mean BMI fell significantly more in the n-3 LCPUFA group than in the placebo group (-0.29 ± 0.06 kg/m2 vs. -0.02 ± 0.06 kg/m2, P = 0.003). Similar results were found in the changes of suboptimal health status and suboptimal cardiovascular health status (P < 0.05 for all). In a multivariate analysis, the n-3 LCPUFA group was 5.44 (1.15, 25.67) times more likely to have optimal cardiovascular health status after treatment.

CONCLUSIONS:

n-3 LCPUFA intake improved suboptimal cardiovascular health in this placebo-controlled, randomized, double-blind trial.

TRIAL REGISTRATION:

This study is registered at www.clinicaltrials.govNCT02103517.

KEYWORDS:

Cardiovascular risk; Fish oil; Metabolic disorders; Suboptimal cardiovascular health; Suboptimal health; n-3 long-chain polyunsaturated fatty acids

PMID:
29066159
DOI:
10.1016/j.numecd.2017.09.004
[Indexed for MEDLINE]

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