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Semin Immunol. 2017 Dec;34:52-60. doi: 10.1016/j.smim.2017.10.001. Epub 2017 Oct 21.

Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System.

Author information

1
Institut Català de Nanociència i Nanotecnologia (ICN2), CSIC and The Barcelona Institute of Science and Technology (BIST), Campus UAB, 08193, Bellaterra, Barcelona, Spain; Universitat Autonoma de Barcelona, 08193, Bellaterra, Spain.
2
Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain; Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
3
Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain.
4
Applied Nanoparticles, S.L., C/Corsega 516, 2n, 1a, 08025 Barcelona, Spain.
5
Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
6
Institut Català de Nanociència i Nanotecnologia (ICN2), CSIC and The Barcelona Institute of Science and Technology (BIST), Campus UAB, 08193, Bellaterra, Barcelona, Spain.
7
Universitat Autonoma de Barcelona, 08193, Bellaterra, Spain; Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain.
8
Institut Català de Nanociència i Nanotecnologia (ICN2), CSIC and The Barcelona Institute of Science and Technology (BIST), Campus UAB, 08193, Bellaterra, Barcelona, Spain; Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), P. Lluís Companys 23, 08010 Barcelona, Spain. Electronic address: victor.puntes@icn2.cat.

Abstract

The interaction of inorganic nanoparticles and many biological fluids often withstands the formation of a Protein Corona enveloping the nanoparticle. This Protein Corona provides the biological identity to the nanoparticle that the immune system will detect. The formation of this Protein Corona depends not only on the composition of the nanoparticle, its size, shape, surface state and exposure time, but also on the type of media, nanoparticle to protein ratio and the presence of ions and other molecular species that interfere in the interaction between proteins and nanoparticles. This has important implications on immune safety, biocompatibility and the use of nanoparticles in medicine.

KEYWORDS:

Homo and Hetero-aggregation; Immune Response; Inorganic Nanoparticles; Nanoparticle-Protein Corona; Protein Corona Characterization; Vroman Effect

PMID:
29066063
DOI:
10.1016/j.smim.2017.10.001
[Indexed for MEDLINE]

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