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J Nanobiotechnology. 2017 Oct 25;15(1):75. doi: 10.1186/s12951-017-0310-5.

Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms.

Wei M1,2, Li S1,2, Le W3,4,5.

Author information

1
Liaoning Provincial Center for Clinical Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, 116021, People's Republic of China.
2
Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, 116021, People's Republic of China.
3
Liaoning Provincial Center for Clinical Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, 116021, People's Republic of China. wdle@sibs.ac.cn.
4
Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, 116021, People's Republic of China. wdle@sibs.ac.cn.
5
Collaborative Innovation Center for Brain Science, The First Affiliated Hospital, Dalian Medical University, Dalian, 116021, People's Republic of China. wdle@sibs.ac.cn.

Abstract

Stem cells are unspecialized cells that have the potential for self-renewal and differentiation into more specialized cell types. The chemical and physical properties of surrounding microenvironment contribute to the growth and differentiation of stem cells and consequently play crucial roles in the regulation of stem cells' fate. Nanomaterials hold great promise in biological and biomedical fields owing to their unique properties, such as controllable particle size, facile synthesis, large surface-to-volume ratio, tunable surface chemistry, and biocompatibility. Over the recent years, accumulating evidence has shown that nanomaterials can facilitate stem cell proliferation and differentiation, and great effort is undertaken to explore their possible modulating manners and mechanisms on stem cell differentiation. In present review, we summarize recent progress in the regulating potential of various nanomaterials on stem cell differentiation and discuss the possible cell uptake, biological interaction and underlying mechanisms.

KEYWORDS:

Differentiation; Nanomaterials; Stem cells

PMID:
29065876
PMCID:
PMC5655945
DOI:
10.1186/s12951-017-0310-5
[Indexed for MEDLINE]
Free PMC Article

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