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Dev Cell. 2017 Oct 23;43(2):124-140. doi: 10.1016/j.devcel.2017.09.016.

The Origin of Animal Multicellularity and Cell Differentiation.

Author information

1
Howard Hughes Medical Institute and the Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
2
Howard Hughes Medical Institute and the Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. Electronic address: nking@berkeley.edu.

Abstract

Over 600 million years ago, animals evolved from a unicellular or colonial organism whose cell(s) captured bacteria with a collar complex, a flagellum surrounded by a microvillar collar. Using principles from evolutionary cell biology, we reason that the transition to multicellularity required modification of pre-existing mechanisms for extracellular matrix synthesis and cytokinesis. We discuss two hypotheses for the origin of animal cell types: division of labor from ancient plurifunctional cells and conversion of temporally alternating phenotypes into spatially juxtaposed cell types. Mechanistic studies in diverse animals and their relatives promise to deepen our understanding of animal origins and cell biology.

KEYWORDS:

Choanozoa; choanoflagellates; evo-devo; evolutionary cell biology; metazoan origins; multicellularity

PMID:
29065305
PMCID:
PMC6089241
DOI:
10.1016/j.devcel.2017.09.016
[Indexed for MEDLINE]
Free PMC Article

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