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Anesth Analg. 2018 May;126(5):1505-1508. doi: 10.1213/ANE.0000000000002562.

Incidence of Anaphylaxis Associated With Sugammadex.

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From the Department of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan.
Department of Anesthesiology, Mitsui Memorial Hospital, Tokyo, Japan.


We retrospectively investigated the incidence of potential sugammadex-induced anaphylaxis at a single center in Japan over a period of 3 years. The overall incidence of intraoperative hypersensitivity reaction was 0.22% (95% confidence interval [CI], 0.17%-0.29%), and the incidence of anaphylaxis was 0.059% (95% CI, 0.032%-0.10%). The total number of patients who received sugammadex during the study period was 15,479, and the incidence of anaphylaxis associated with sugammadex was 0.039% (n = 6; 95% CI, 0.014%-0.084%). This result implies that the incidence of sugammadex-associated anaphylaxis could be as high as that for succinylcholine or rocuronium. A prospective study, including testing for identification of cause, is necessary to confirm the exact incidence of sugammadex-induced anaphylaxis; however, the present finding calls attention to this potential.

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