Format

Send to

Choose Destination
Int J Environ Res Public Health. 2017 Oct 24;14(10). pii: E1282. doi: 10.3390/ijerph14101282.

Endocrine Disruptors Leading to Obesity and Related Diseases.

Author information

1
Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece. dimitriospetrakis@hotmail.com.
2
Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece. loukia.vassilopoulou@gmail.com.
3
Department of Urology, University General Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, Crete, Greece. mamoulak@uoc.gr.
4
Department of Obstetrics and Gynecology, Venizeleio-Pananio General Hospital of Heraklion, 71409 Heraklion, Crete, Greece. chrispsycharakis@hotmail.com.
5
Crete Fertility Center, 56, Arch. Makariou & Sof. Venizelou Str., 71202 Heraklion, Crete, Greece. alikianifantaki@gmail.com.
6
Mitera Hospital, 71409 Heraklion, Crete, Greece. stavros.sifakis@yahoo.com.
7
Department of Toxicology, Faculty of Pharmacy, University of Medicine and Pharmacy, Petru Rares, 200349 Craiova, Romania. ancadocea@gmail.com.
8
Laboratory of Anatomy-Histology-Embryology, Medical School, University of Crete, 71003 Heraklion, Crete, Greece. jtsiaoussis@hotmail.com.
9
Department of Obstetrics and Gynecology, Medical School, University of Crete, 71003 Heraklion, Crete, Greece. makrygia@uoc.gr.
10
Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece. tsatsaka@uoc.gr.

Abstract

The review aims to comprehensively present the impact of exposure to endocrine disruptors (EDs) in relation to the clinical manifestation of obesity and related diseases, including diabetes mellitus, metabolic syndrome, cardiovascular diseases, carcinogenesis and infertility. EDs are strong participants in the obesity epidemic scenery by interfering with cellular morphological and biochemical processes; by inducing inflammatory responses; and by presenting transcriptional and oncogenic activity. Obesity and lipotoxicity enhancement occur through reprogramming and/or remodeling of germline epigenome by exposure to EDs. Specific population groups are vulnerable to ED exposure due to current dietary and environmental conditions. Obesity, morbidity and carcinogenicity induced by ED exposure are an evolving reality. Therefore, a new collective strategic approach is deemed essential, for the reappraisal of current global conditions pertaining to energy management.

KEYWORDS:

carcinogenesis; cardiovascular diseases; diabetes mellitus; endocrine disruptors; infertility; metabolic syndrome; obesity; pesticides

PMID:
29064461
PMCID:
PMC5664782
DOI:
10.3390/ijerph14101282
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center