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Angew Chem Int Ed Engl. 2018 Apr 9;57(16):4143-4148. doi: 10.1002/anie.201708408. Epub 2017 Nov 28.

Directed Evolution: Bringing New Chemistry to Life.

Author information

1
Division of Chemistry and Chemical Engineering, California Institute of Technology 210-41, 1200 E. California Blvd., Pasadena, CA, 91125, USA.

Abstract

Tailor-made: Discussed herein is the ability to adapt biology's mechanisms for innovation and optimization to solving problems in chemistry and engineering. The evolution of nature's enzymes can lead to the discovery of new reactivity, transformations not known in biology, and reactivity inaccessible by small-molecule catalysts.

KEYWORDS:

biocatalysis; enzymes; heme proteins; protein engineering; synthetic methods

PMID:
29064156
PMCID:
PMC5901037
DOI:
10.1002/anie.201708408
[Indexed for MEDLINE]
Free PMC Article

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