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Eur J Epidemiol. 2017 Sep;32(9):807-850. doi: 10.1007/s10654-017-0321-4. Epub 2017 Oct 24.

The Rotterdam Study: 2018 update on objectives, design and main results.

Author information

1
Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. m.a.ikram@erasmusmc.nl.
2
Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands. m.a.ikram@erasmusmc.nl.
3
Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
4
Department of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
5
Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
6
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
7
Department of Gastro-Enterology, Erasmus Medical Center, Rotterdam, The Netherlands.
8
Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.
9
Department of Otolaryngology, Erasmus Medical Center, Rotterdam, The Netherlands.
10
Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.
11
Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.
12
Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands.
13
Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
14
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Abstract

The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1500 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.

KEYWORDS:

Biomarkers; Cardiovascular diseases; Cohort study; Dermatological diseases; Endocrine diseases; Epidemiologic methods; Genetic epidemiology; Liver diseases; Neurological diseases; Oncology; Ophthalmic diseases; Otolaryngological diseases; Pharmacoepidemiology; Psychiatric diseases; Renal diseases; Respiratory diseases

PMID:
29064009
PMCID:
PMC5662692
DOI:
10.1007/s10654-017-0321-4
[Indexed for MEDLINE]
Free PMC Article

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