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Eur J Epidemiol. 2017 Oct;32(10):931-938. doi: 10.1007/s10654-017-0320-5. Epub 2017 Oct 23.

Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium.

Author information

1
Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave., Kresge 905, Boston, MA, 02115, USA.
2
Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
3
Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
4
Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
5
Boston University School of Medicine, Boston, MA, USA.
6
The Framingham Heart Study, Framingham, MA, USA.
7
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
8
INSERM, Univ Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France.
9
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
10
University of Texas School of Public Health, Houston, TX, USA.
11
Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
12
University of Cambridge, Cambridge, UK.
13
Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, F-33000, France.
14
Department of Neurology, Memory Clinic, Bordeaux University Hospital, Bordeaux, France.
15
University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA.
16
Icelandic Heart Association, Kópavogur, Iceland.
17
Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
18
Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK.
19
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
20
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
21
Departments of Neurology & Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
22
Newcastle University, Newcastle upon Tyne, UK.
23
University of Mississippi Medical Center, Jackson, MS, USA.
24
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
25
Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave., Kresge 905, Boston, MA, 02115, USA. ahofman@hsph.harvard.edu.
26
Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands. ahofman@hsph.harvard.edu.

Abstract

Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports are conflicting or inconclusive with regard to the impact of gender and education with underlying causes of a presumed declining trend remaining largely unidentified. The Alzheimer Cohorts Consortium aggregates data from nine international population-based cohorts to determine changes in the incidence of dementia since 1990. We will employ Poisson regression models to calculate incidence rates in each cohort and Cox proportional hazard regression to compare 5-year cumulative hazards across study-specific epochs. Finally, we will meta-analyse changes per decade across cohorts, and repeat all analysis stratified by sex, education and APOE genotype. In all cohorts combined, there are data on almost 69,000 people at risk of dementia with the range of follow-up years between 2 and 27. The average age at baseline is similar across cohorts ranging between 72 and 77. Uniting a wide range of disease-specific and methodological expertise in research teams, the first analyses within the Alzheimer Cohorts Consortium are underway to tackle outstanding challenges in the assessment of time-trends in dementia occurrence.

KEYWORDS:

Alzheimer disease; Cohort analysis; Consortium; Epidemiology

PMID:
29063414
PMCID:
PMC5680377
DOI:
10.1007/s10654-017-0320-5
[Indexed for MEDLINE]
Free PMC Article

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